PHYSICOCHEMICAL PROPERTIES AND IN VITRO STABILITY STUDIES OF GREEN SYNTHESIZED GOLD NANOPARTICLES USING PELARGONIUM SIDOIDES

Authors

  • UM Badeggi DEPARTMENT OF CHEMISTRY, FACULTY OF APPLIED AND NATURAL SCIENCES, IBRAHIM BADAMASI BABANGIDA UNIVERSITY, LAPAI, PMB 11, NIGER STATE, NIGERIA
  • BA Lawal DEPARTMENT OF PHARMACOGNOSY AND DRUG DEVELOPMENT, FACULTY OF PHARMACEUTICAL SCIENCES, UNIVERSITY OF ILORIN, KWARA STATE, NIGERIA
  • AO Akinfenwa DEPARTMENT OF CHEMISTRY, CAPE PENINSULA UNIVERSITY OF TECHNOLOGY, BELLVILLE CAMPUS, PO BOX 1906, BELLVILLE 7535, SOUTH AFRICA
  • YO Ayipo DEPARTMENT OF CHEMICAL, GEOLOGICAL AND PHYSICAL SCIENCES, KWARA STATE UNIVERSITY, MALETE, KWARA STATE, NIGERIA
  • Y Azeh DEPARTMENT OF CHEMISTRY, FACULTY OF APPLIED AND NATURAL SCIENCES, IBRAHIM BADAMASI BABANGIDA UNIVERSITY, LAPAI, PMB 11, NIGER STATE, NIGERIA
  • MZ Dagaci DEPARTMENT OF CHEMISTRY, FACULTY OF APPLIED AND NATURAL SCIENCES, IBRAHIM BADAMASI BABANGIDA UNIVERSITY, LAPAI, PMB 11, NIGER STATE, NIGERIA

Keywords:

Pelargonium sidoides; biosynthesis; biomedicals; capping agent; zeta potential

Abstract

In the present study, Pelargonium sidoides (PS) extract was used in the green synthesis of AuNPs that was characterized by UV-Vis, TEM, SAED, EDS, XRD, FTIR, and DLS. UV-Vis showed a surface plasmon resonance (SPR) at ?max of 532 nm while TEM shows that the particles are predominantly spherical and monodispersed. DLS measurement indicated the particle size and the zeta potential to be 27.20 nm and -24.0 mV respectively. The in vitro stability of the hybrid particles in different solutions and buffers (pH 7 and 9) confirmed that the particles are stable over a given period. The method employed is simple, environmentally friendly, and inexpensive. Our studies suggest that the Pelargonium sidoides-gold nanoparticles (PS-AuNPs) may be safely used in biomedical applications such as drug delivery.

 

http://dx.doi.org/10.4314/njt.v39i3.18

Published

2020-06-22

Issue

Section

Chemical, Industrial, Materials, Mechanical, Metallurgical, Petroleum & Production Engineering